Chicken Alfredo Lasagna

Featured in: Everyday Comfort Dishes

This rich and satisfying lasagna combines tender shredded chicken with velvety Alfredo sauce, fresh spinach, and three cheeses in a beautifully layered pasta dish. Baked until golden and bubbly, it serves eight and takes just under 1.5 hours from start to table. Perfect for family dinners or entertaining guests, this Italian-American classic balances creamy textures with savory flavors.

Updated on Sun, 18 Jan 2026 14:52:00 GMT
A close-up of homemade Chicken Alfredo Lasagna, layers of tender chicken, spinach, and creamy sauce in a bubbly, golden-brown dish. Pin Recipe
A close-up of homemade Chicken Alfredo Lasagna, layers of tender chicken, spinach, and creamy sauce in a bubbly, golden-brown dish. | fordishes.com

My neighbor knocked on the door one Sunday evening holding an empty casserole dish, asking if I had anything creamy and filling to feed unexpected guests. I pulled together what was in my fridge, layered it all into a baking dish, and an hour later she came back with the recipe request scribbled on a napkin. That improvised dinner became this lasagna, a dish that feels fancy but comes together with pantry staples and a little patience.

I made this for my sister after her twins were born, and she told me it was the first meal in weeks that didnt taste like cardboard. She ate two pieces standing at the counter still wearing her bathrobe. Sometimes comfort food isnt just about flavor, its about timing and the relief of not having to think.

Ingredients

  • Cooked chicken breast: Rotisserie chicken is my secret shortcut here, the seasoning in the skin adds unexpected depth and saves you from poaching bland meat.
  • Lasagna noodles: Oven ready noodles work beautifully if youre short on time, but boiling regular ones gives you more control over texture.
  • Baby spinach: It wilts down to almost nothing, so dont be shy, pile it in and let it shrink into sweet, earthy pockets between the cheese.
  • Onion and garlic: These two are the foundation, cook them slowly so they sweeten and melt into the sauce rather than biting back.
  • Alfredo sauce: Homemade is luxurious, but a good jar from the store works when life is busy, just taste it first and add a pinch of nutmeg if its too flat.
  • Ricotta cheese: Whole milk ricotta makes the filling cloud like, the egg binds it so it doesnt slide apart when you slice.
  • Mozzarella and Parmesan: Low moisture mozzarella melts without making the dish soupy, and Parmesan on top crisps into golden, salty edges.
  • Italian herbs: Dried basil, oregano, and thyme bring warmth without overpowering the creamy sauce.
  • Fresh parsley: A handful at the end brightens everything and makes it look like you fussed more than you did.

Instructions

Get the oven ready:
Preheat to 375°F and grease your baking dish lightly so the bottom layer doesnt stick. A quick swipe of butter or oil is all you need.
Cook the noodles:
If using regular lasagna noodles, boil them until just al dente, they will finish cooking in the oven. Lay them flat on a towel so they dont clump together.
Sauté the aromatics:
Heat a splash of olive oil in a skillet and cook the onion until it turns translucent and soft. Add the garlic and stir for a minute, just until fragrant, not browned.
Wilt the spinach:
Toss in the chopped spinach and let it collapse into the pan, stirring gently. Once wilted, remove from heat and let it cool so it doesnt scramble the egg in the ricotta.
Mix the ricotta filling:
In a bowl, combine ricotta, egg, half the Parmesan, Italian herbs, salt, and pepper. Fold in the cooled spinach mixture until everything is evenly distributed and creamy.
Start layering:
Spread half a cup of Alfredo sauce on the bottom of the dish to prevent sticking. Lay down four noodles, slightly overlapping if needed.
Build the first layer:
Spread half the ricotta spinach mixture over the noodles, scatter half the chicken on top, drizzle with a cup of Alfredo, and sprinkle with mozzarella. Press gently so everything settles.
Repeat the second layer:
Add another layer of noodles, the remaining ricotta mixture, remaining chicken, more Alfredo, and another layer of mozzarella. Each layer should feel generous and thick.
Top it off:
Finish with the last noodles, pour the remaining Alfredo over everything, and cover with the rest of the mozzarella and Parmesan. The cheese should blanket the top completely.
Bake covered:
Cover tightly with foil and bake for 30 minutes so the noodles soften and the flavors meld. The foil traps steam and keeps the top from drying out.
Finish uncovered:
Remove the foil and bake another 20 to 25 minutes until the top is bubbly and golden. Watch for those crispy, caramelized edges.
Rest before serving:
Let the lasagna sit for 10 to 15 minutes before slicing. This helps it firm up so the layers dont slide apart on the plate.
Slice of rich Chicken Alfredo Lasagna on a white plate, served with a fresh green salad for a comforting Italian-American dinner. Pin Recipe
Slice of rich Chicken Alfredo Lasagna on a white plate, served with a fresh green salad for a comforting Italian-American dinner. | fordishes.com

One winter evening, I made this for a potluck and watched a friend scrape the corner of the pan with her fork, chasing every bit of crispy cheese. She looked up and said, This is what I want to eat when everything else feels too complicated. That moment reminded me that recipes like this arent just instructions, they are permission to slow down and savor something rich and simple.

Make Ahead Magic

Assemble the entire lasagna up to the baking step, cover it tightly with plastic wrap and foil, and refrigerate for up to 24 hours. When youre ready, let it sit at room temperature for 20 minutes, then bake as directed, adding an extra 10 minutes if its still cold in the center. You can also freeze it unbaked for up to three months, just thaw it overnight in the fridge before baking. This trick has saved me more times than I can count when I needed dinner to feel effortless.

Swaps and Variations

If youre out of spinach, kale works beautifully, just massage it first to soften the leaves. Swap chicken for cooked turkey, shrimp, or even crumbled Italian sausage if you want a heartier flavor. For a lighter version, use part skim ricotta and reduce the mozzarella by half, though I wont lie, the full fat version is where the magic lives. Gluten free noodles hold up well here, and if dairy is an issue, cashew based Alfredo and vegan cheeses can step in with surprising success.

Serving Suggestions

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This lasagna is rich enough to be the star, so keep the sides simple and bright. A crisp green salad with lemon vinaigrette cuts through the creaminess, and garlic bread is optional but always welcome. I like to pour a glass of chilled Pinot Grigio or sparkling water with a squeeze of lime. Leftovers reheat beautifully in the oven at 350°F covered with foil, or in the microwave if youre in a hurry.

  • Let each slice cool on the plate for a minute so the layers set and you get a clean, pretty cut.
  • Garnish with fresh parsley or a sprinkle of red pepper flakes for a little heat and color.
  • If youre feeding a crowd, double the recipe and use two pans, this one always disappears fast.
Freshly baked Chicken Alfredo Lasagna in a ceramic dish, garnished with parsley and ready to serve with garlic bread. Pin Recipe
Freshly baked Chicken Alfredo Lasagna in a ceramic dish, garnished with parsley and ready to serve with garlic bread. | fordishes.com

This lasagna has become the dish I make when I want to feel like everything is going to be okay, when the kitchen smells like butter and garlic and the oven hums warmly in the corner. I hope it brings that same comfort to your table, one creamy, cheesy layer at a time.

Recipe FAQs

Can I prepare this ahead of time?

Yes, you can assemble the entire dish up to 24 hours in advance. Cover with foil and refrigerate. Add 10-15 minutes to the baking time if baking directly from the refrigerator.

What's the best way to prevent a watery lasagna?

Ensure your spinach is thoroughly wilted and cooled before mixing into the ricotta. If using fresh spinach, squeeze out excess moisture. Don't overload the layers with sauce—use the amounts specified.

Can I use store-bought Alfredo sauce?

Absolutely. Store-bought Alfredo sauce works wonderfully and saves time. Choose a quality brand for best flavor. You can also make homemade sauce by simmering butter, cream, Parmesan, and garlic.

How do I know when it's fully cooked?

The lasagna is done when the top is golden brown, the edges are bubbling, and a knife inserted into the center comes out hot. The cheese should be melted and slightly browned.

Why should it rest before slicing?

Resting for 10-15 minutes allows the layers to set and the cheese to firm up slightly, making clean, intact slices. Cutting too early will cause the filling to spill out.

Can I substitute vegetables in this dish?

Yes. Kale, zucchini, or mushrooms work well as spinach alternatives. You can also add roasted red peppers or sun-dried tomatoes for extra flavor without changing the cooking method.

Chicken Alfredo Lasagna

Layered chicken, creamy Alfredo sauce, spinach, and melted cheese nestled between pasta sheets for an Italian-American comfort classic.

Prep Duration
30 mins
Cooking Duration
55 mins
Complete Time
85 mins
Recipe by Fordishes Ava Reynolds


Skill Level Medium

Cuisine Italian-American

Makes 8 Number of Servings

Diet Details None specified

Ingredient List

Proteins

01 3 cups cooked chicken breast, shredded or diced

Pasta

01 12 lasagna noodles, regular or oven-ready

Vegetables

01 2 cups fresh baby spinach, roughly chopped
02 1 medium onion, finely diced
03 3 cloves garlic, minced

Sauces & Dairy

01 4 cups Alfredo sauce, store-bought or homemade
02 2 cups whole milk ricotta cheese
03 2 cups shredded mozzarella cheese
04 1 cup grated Parmesan cheese
05 1 large egg

Spices & Seasonings

01 1 teaspoon dried Italian herbs
02 1/2 teaspoon salt
03 1/4 teaspoon black pepper
04 2 tablespoons fresh parsley, chopped

Directions

Step 01

Prepare Oven and Baking Dish: Preheat oven to 375°F. Lightly grease a 9x13-inch baking dish with cooking spray or butter.

Step 02

Cook Lasagna Noodles: If using regular lasagna noodles, cook according to package instructions until al dente. Drain thoroughly and lay flat on parchment paper to prevent sticking.

Step 03

Sauté Aromatics: Heat a large skillet over medium heat with a splash of olive oil. Sauté diced onion for 3 to 4 minutes until softened. Add minced garlic and cook for 1 minute more until fragrant.

Step 04

Wilt Spinach: Stir in chopped spinach and cook for approximately 2 minutes until completely wilted. Remove from heat and allow to cool slightly before proceeding.

Step 05

Prepare Ricotta Mixture: In a medium bowl, combine ricotta cheese, egg, half of the Parmesan cheese, Italian herbs, salt, and black pepper. Fold in the cooled spinach mixture until evenly distributed.

Step 06

Layer Base: Spread 1/2 cup of Alfredo sauce evenly across the bottom of the prepared baking dish to prevent sticking and add moisture.

Step 07

Create First Layers: Arrange 4 lasagna noodles over the sauce. Spread half of the ricotta-spinach mixture over the noodles. Scatter half of the chicken evenly across the layer. Drizzle with 1 cup of Alfredo sauce and sprinkle with 2/3 cup mozzarella cheese.

Step 08

Create Second Layers: Repeat with another layer of 4 noodles, remaining ricotta-spinach mixture, remaining chicken, 1 cup of Alfredo sauce, and 2/3 cup mozzarella cheese.

Step 09

Create Final Layer: Top with the final 4 noodles, remaining Alfredo sauce, remaining mozzarella cheese, and reserved Parmesan cheese.

Step 10

Bake Covered: Cover the baking dish tightly with foil and bake for 30 minutes at 375°F. This prevents the top from browning too quickly while the interior cooks through.

Step 11

Finish Baking: Remove foil carefully and bake for an additional 20 to 25 minutes until the lasagna is bubbly around the edges and the top is golden brown.

Step 12

Rest and Serve: Allow the lasagna to stand for 10 to 15 minutes before slicing. This resting period helps the layers set for cleaner portions. Garnish with fresh parsley if desired before serving.

Needed Equipment

  • 9x13-inch baking dish
  • Large skillet
  • Medium mixing bowl
  • Saucepan for Alfredo sauce if preparing homemade
  • Measuring cups and spoons
  • Aluminum foil

Allergy Info

Double-check ingredients for allergens and speak with a healthcare provider if you're unsure.
  • Contains wheat from pasta
  • Contains milk from cheese and sauce
  • Contains eggs
  • May contain tree nuts if using nut-based Alfredo sauce

Nutrition Information (per serving)

For informational use only—doesn't replace personalized medical direction.
  • Calories: 510
  • Fats: 27 g
  • Carbohydrates: 33 g
  • Proteins: 34 g